After a penetrating lesion within the central nervous system, astrocytes enlarge, divide, and participate in creating an setting that adversely affects neuronal regeneration. We have lately proven that the neural cell adhesion molecule (N-CAM) partially inhibits the division of early postnatal rat astrocytes in vitro. Animals were lesioned within the cerebral cortex, hippocampus, or striatum with a Hamilton syringe and needle at defined stereotaxic positions. On one facet, the lesions were concomitantly infused with N-CAM or with one of the N-CAM-related molecules. As a management , a peptide of the same composition because the N-CAM decapeptide but of random sequence was infused on the contralateral aspect of the mind. The inhibition was greatest in the cortical lesion sites (approximately 50%) and was less pronounced within the hippocampus (approximately 25%) and striatum (approximately 20%). Two weeks after the lesion, the cerebral cortical websites infused with N-CAM continued to exhibit a considerably smaller population of dividing astrocytes than the websites on the other facet.
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- Alonso G, Privat A. Reactive astrocytes concerned within the formation of lesional scars differ within the mediobasal hypothalamus and in other forebrain areas.
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Alonso G, Privat A. Reactive astrocytes involved in the formation of lesional scars differ within the mediobasal hypothalamus and in other forebrain regions. Brodkey JA, Gates MA, Laywell ED, Steindler DA. The complicated nature of interactive neuroregeneration-related molecules. Rudge JS, Silver J. Inhibition of neurite outgrowth on astroglial scars in vitro. Applications of Proteomics to Nerve Regeneration Research. Birding, and alternatives s3x cam to help bird conservation. Get the latest news from us on tips on how to grow your small business – delivered straight to your inbox.
Immunoelectron Microscopic Localization Of Neural Cell Adhesion Molecules L1, N
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Neural Cell Adhesion Molecule N
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Del Rio JA, Soriano E. Immunocytochemical detection of 5′-bromodeoxyuridine incorporation in the central nervous system of the mouse. Giulian D, Chen J, Ingeman JE, George JK, Noponen M. The function of mononuclear phagocytes in wound healing after traumatic injury to adult mammalian mind. Smith GM, Rutishauser U, Silver J, Miller RH. Maturation of astrocytes in vitro alters the extent and molecular basis of neurite outgrowth. Full textual content is available as a scanned copy of the unique print version. Get a printable copy of the whole article (1.6M), or click on a page image under to browse web page by page. Links to PubMed are additionally available for Selected References. Immunohistological localization of the adhesion molecules L1, N-CAM, and MAG within the developing and adult optic nerve of mice.
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